β- thalassemia major (β-TM) is one of the most common inherited single gene disorder .Children with Thalassemia frequently have poor growth and delayed pubertal development. Selenium and manganese are factors responsible for growth and puberty disorders in thalassemic patients.
Assessment of serum levels of selenium and manganese in patients with β thalassemia major in Pediatric Haematology Clinic in Beni Suef University Hospital. Blood was taken from 50 pediatric patients with b thalassemia major, and 50 normal children as controls . All children were age and sex matched . all children were subjected to full history taking and full clinical examination and investigation was done in the form of CBC, serum Ferritin , serum Selenium and Manganese were measured using spectrophotometer.
Patients with β- thalassemia major have high serum manganese level as compared to normal controls with P value of (0.000), while serum selenium level is insignificant as compared to normal controls with P value of (0.119)