Background: Acne is a common chronic skin disease with a multifactorial aetiology and pathogenesis. Recently, circular RNAs (circRNAs) have been identified as a key factor in regulating gene expression through circRNA–miRNA–mRNA networks in many biological processes and human diseases. However, the circRNAs expression in patients with acne is still unknown, Aim and Objectives: To evaluate circular RNA Expression in Patient with Acne and to correlate its level with acne severity, Subjects and Methods: this was a case control study was conducted at conducted at Dermatology outpatient clinic at Beni-Suef University hospital including 40 with acne vulgaris and 40 normal as control. The duration of the study ranged from 6 months, Results: The mean CIRCULAR RNA 0001073 for cases group was 0.47 (±0.3 SD) with range (0.11-1.2) and that the mean CIRCULAR RNA 0001073 for control group was 1.03 (±0.1 SD) with range (0.95-1.2), and There was high statistically significant difference between the studied groups as regard CIRCULAR RNA 0001073. Conclusion: This study firstly showed that circRNAs were differentially expressed in severe acne and suggested that circRNAs could be used as a potential biomarker for the drug targets of acne.