The goal of this study is to Correlate between Vitamin D receptor polymorphism (FOKI) and lupus nephritis. Eighty subjects were included in this study. They were divided into two groups as follows: Control group: consisted of twenty apparently healthy volunteers of comparable age and socioeconomic status to the patients group. Patients group: consisted of sixty patients with SLE. They were selected from the Internal Medicine departement and Rheumatology out patient clinic of Beni-suef University hospital. In this study, Regarding CBC changes ,The prevalence of  thrombocytopenia and lymphopenia was significantly higher among SLE patients compared to our controls, However the prevalence of lymphopenia and leucopenia was significantly higher among SLE patients with GG genotype compared to SLE patients with AG and AA mutants ,Regarding liver function tests, The mean serum Albumin level was significantly lower among SLE patients compared to controls .Antinuclear antibody titre was significantly higher among SLE patients than controls ,Also Anti Ds DNA is represented in SLE patients in ahigh titre than healthy controls ,Furthermore, All SLE patients with GG genotypes had positive  Anti Ds DNA(  100%) compared to  SLE  patients with AG ( 0,0) and AA ( 0,0) mutants. It is recommended to carry out further studies on FOKI gene polymorphisms in larger groups of patients and controls.