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254009

Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Internal medicine ·

Abstract

There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons via investigating its potential role in the pathogenesis of this disease. A case control study for detection of Desmoglein-3 autoantibodies in serum of 40 lichen planus patients and 40 healthy controls using enzyme-linked immunosorbent assay (ELISA) technique.The patients and healthy controls were recruited from Dermatology outpatient clinic at Beni-Suef University hospital. The measurement of anti Dsg3 antibodies in LP patients was significantly higher as compared to normal control persons. The mean scores were 1361.37 ± 300.5 in oral LP & 2118.70 ± 584.37 in cutaneous LP vs. 66.98 ±70.95 in controls (p-value < 0.001). Desmoglein-3 auto-antibodies in LP may have a role in the pathogenesis of the disease. Further investigations are needed for detection of Dsg 3 auto-antibodies in LP skin biopsy or blood samples by other methods such as Immunofluorescence.

DOI

10.21608/ejmr.2022.254009

Keywords

lichen planus, Dsg3, Autoantibody

Authors

First Name

Abd-El Aziz

Last Name

El-Rifaie

MiddleName

-

Affiliation

Dermatology Department-Faculty of Medicine, Beni-Suef University.

Email

-

City

-

Orcid

-

First Name

Laila

Last Name

Rashed

MiddleName

Ahmed

Affiliation

Professor of Biochemistry-Faculty of Medicine, Cairo University.

Email

lailarashed@kasralainy.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Abdellatif

MiddleName

El sayed Ahmed

Affiliation

Dermatology Department-Faculty of Medicine, Beni-Suef University.

Email

monaelsayedabdellatif@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Mohamed

MiddleName

Abdel Ghany

Affiliation

Dermatology Department-Faculty of Medicine, Beni-Suef University.

Email

m_asmaa22@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

3

Related Issue

32884

Issue Date

2022-07-01

Receive Date

2022-08-10

Publish Date

2022-07-01

Page Start

105

Page End

116

Print ISSN

2682-4396

Online ISSN

2682-440X

Article File

EJMR_Volume 3_Issue 3_Pages 105-116.pdf

PDF . 536.1kB

Link

https://ejmr.journals.ekb.eg/article_254009.html

Detail API

https://ejmr.journals.ekb.eg/service?article_code=254009

Order

254,009

Type

Original Article

Type Code

1,224

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Research

Publication Link

https://ejmr.journals.ekb.eg/

MainTitle

Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus

Details

Type

Article

Created At

22 Jan 2023