Subjects
-Abstract
There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons via investigating its potential role in the pathogenesis of this disease. A case control study for detection of Desmoglein-3 autoantibodies in serum of 40 lichen planus patients and 40 healthy controls using enzyme-linked immunosorbent assay (ELISA) technique.The patients and healthy controls were recruited from Dermatology outpatient clinic at Beni-Suef University hospital. The measurement of anti Dsg3 antibodies in LP patients was significantly higher as compared to normal control persons. The mean scores were 1361.37 ± 300.5 in oral LP & 2118.70 ± 584.37 in cutaneous LP vs. 66.98 ±70.95 in controls (p-value < 0.001). Desmoglein-3 auto-antibodies in LP may have a role in the pathogenesis of the disease. Further investigations are needed for detection of Dsg 3 auto-antibodies in LP skin biopsy or blood samples by other methods such as Immunofluorescence.
DOI
10.21608/ejmr.2022.254009
Keywords
lichen planus, Dsg3, Autoantibody
Authors
MiddleName
-Affiliation
Dermatology Department-Faculty of Medicine, Beni-Suef University.
Email
-City
-Orcid
-Affiliation
Professor of Biochemistry-Faculty of Medicine, Cairo University.
Email
lailarashed@kasralainy.edu.eg
City
-Orcid
-Affiliation
Dermatology Department-Faculty of Medicine, Beni-Suef University.
Email
monaelsayedabdellatif@yahoo.com
City
-Orcid
-Affiliation
Dermatology Department-Faculty of Medicine, Beni-Suef University.
City
-Orcid
-Link
https://ejmr.journals.ekb.eg/article_254009.html
Detail API
https://ejmr.journals.ekb.eg/service?article_code=254009
Publication Title
Egyptian Journal of Medical Research
Publication Link
https://ejmr.journals.ekb.eg/
MainTitle
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