The goal of this study is to study the association of circulating level of Irisin with the anthropometric and metabolic parameters in normal weight, overweight and obese children. It's a cross sectional study conducted on 69 children, grouped into 3 groups ; normal weight (BMI<85th), overweight (BMI≥85th), and obese group (BMI≥ 95th percentile for age and sex) (39 males and 30 females), (20 normal weight, 13 overweight, 36 obese children). aged 6-18 years. All are  recruited from Endocrinology Pediatric clinic in Beni Suef University. All participants were subjected to history taking and clinical examination, anthropometric assessment (weight, height, pubertal assessment, waist circumference and hip circumference) and laboratory tests (Serum Irisin, serum cholesterol, serum high density lipoprotein, serum triglycerides, serum fasting insulin, serum fasting glucose, oral glucose tolerance test). Insulin resistance and sensitivity were assessed by calculating HOMA-IR. The obese group of 36 children (52.2%) had a higher level of Irisin than the normal weight and the overweight groups (P-value<0.001). The obese group had a significant higher prevalence of metabolic syndrome regarding the MSC Cook's and the MSC deFerranti criteria. The obese group had a significant linear positive correlation between the Irisin level and BP, BMI, cholesterol level, fasting insulin, fasting glucose, the number of criteria of Metabolic Syndrome as regards International Diabetic Federation and the HOMA IR score. Results revealed that Irisin as well as HOMA-IR can predict presence of metabolic syndrome with high sensitivity and specificity at different levels.