The goal of this study is to measure serum level of I Kappa B in patients with psoriasis in comparison with healthy controls. 50 psoriatic patients and 40 age & gender matched apparently healthy controls were included in the study, patients were classified according to Psoriasis Area & Surface Index (PASI) score and serum samples for all participants were taken to measure I Kappa B level for each. The level of serum I Kappa B was found to be significantly lower in the patients (3.96 ±1.96)  than in controls (11.02 ±2.22). This difference was of statistical significance (p-value =0.001).