Aim: The goal of this study was to determine changes in portal pressure hemodynamics of HCC patients after their management using transarterial chemoembolization (TACE). Twenty five patients with HCC underwent TACE. Medical history in addition to investigations were carried out including Doppler ultrasound for assessment of portal hypertension (PHT )parameters, and then repeated 3 months after TACE. Results: TACE had resulted in a markedly increased liver vascular index with significant reduction in hepatic artery resistive index following therapy. TACE was accompanied by improvement of PHT parameters. Doppler ultrasound might be used as a reliable and efficient tool for assessment of PHT changes. Conclusion: Locoregional therapy has become increasingly pivotal for HCC patients as a result of advances in approaches, survival benefit, and a favorable safety profile, despite curative measures including surgical resection and liver transplantation are still the gold standard.