The aim of this study is to study HCV infection in children in beni-suef governorate and to detect epidemiology and risk factors in studied group. HCV antibodies by4^th generation ELISA. , alanine aminotransferase (ALT) levels and aspartate transaminase(AST) were done for children at the age of 6-17years . Every child with positive HCV antibodies was tested for HCV RNA by PCR. We studied 47 children positive for HCVantibody . 41 of them were HCV RNA positive and 6 of them had negative HCV RNA.Blood transfusion,frequent iv injection,hospitalization,previous operation,family history of HCV infection,circumcision and ear piercing are significant risk factors for infection.Pallor,jaundice and abdominal distention are common symptoms among HcvAb positive childrens. 100% of negative cases in HCV.Ab analysis were the same in PCR analysis in contrast from positive cases where 87% of positive cases in PCR agreed with HCV.Ab analysis but 13% of cases were negatively infected with HCV.ALT and AST were significantly higher in positive cases with HCVAb and PCR as compared to negative cases.