Background: Posterior capsular opacification (PCO), also called 'secondary' or 'after' cataract, develops a few months to a few years over the clear posterior capsule after an uncomplicated cataract surgery that causes decreased vision. Purpose: To evaluate the impact of Neodymium-doped Yttrium Aluminum-Garnet (Nd: YAG) laser capsulotomy on the central macular thickness (CMT) by optical coherence tomography (OCT) in patients with opacified posterior capsule. Patients and Methods: This is a prospective clinical study conducted on 30 pseudophakic patients recruited from Luxor International Hospital and Beni-Suef University Hospital during the period from December 2018 through August 2019. Their age ranged from 40 – 70 years with a mean ± SD of 56.0 ± 8.89 years. There were 19 females (63.3%) and 11 males (36.7%).  Results: There was highly statistically significant increase in CMT 1 week post YAGYAG laser than pre-YAGYAG with a mean thickness of 253.80 ± 14.03 µ vs 241.53 ± 10.22  µ respectively with a P-value < 0.001. Four weeks post YAGYAG,, CMT decreased to 247.27 ± 12.54 µ (P= 0.186) which is non significant. At 12 weeks post YAGYAG CMT decreased to 243.27 ± 12.69 .with p-value < 0.001 which is highly statistically significant. Conclusion: Increased CMT was reported as complication of YAG laser posterior capsulotomy. Although this is not clinically observed but follow up with OCT revealed these changes. However, this might not necessitate regular prophylactic treatment.