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216583

Evaluation of Addition Of Sildenafil Citrate On Fetal Growth And Doppler Indices In Treatment of Pregnancy Induced Hypertension

Article

Last updated: 22 Jan 2023

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Tags

Diagnostic

Abstract

Pregnancy induced hypertension (PIH) is the most common complication during pregnancy and it affects up to 12% of pregnancies. It is the leading cause of maternal and fetal morbidity and mortality (1). Sildenafil is a potent and selective inhibitor of cGMP .which results in increased levels of cGMP, leading to smooth muscle relaxation thus mediating improved uteroplacental perfusion and increased fetal growth (12). Objectives:This study is to evaluate effect of sildenafil citrate on fetal growth and Doppler indices in treatment of pregnancy induced hypertension Setting:Department of Obstetrics &Gynecology, Beni-Suef University Hospital. Methods:Patients were divided into two groups: Group A (sildenafil group) were offered Sildenafil 20 mg t.i.d. with a plenty of fluids until delivery in addition to traditional treatment. Group B (Placebo group) received placebo drug with the same shape and texture as sildenafil citrate in addition to traditional treatment.Main outcome measures: Utero placental perfusion, fetal growth and maternal and fetal safety. Results: Sildenafil treatment was associated with a significant decrease of SBP between the two time points (P-value<0.001), a significant decrease of DBP between the two time points (P-value<0.001) and increase in estimated fetal weight by ultrasound (P<0.001). Conclusions: Despite limited data, overall there does not appear to be any severe adverse maternal side effects nor any increase in the rate of stillbirths, neonatal deaths attributed to SC.

DOI

10.21608/ejmr.2022.216583

Keywords

sildenafil, Pregnancy Induced Hypertension, IUGR, Doppler indices

Authors

First Name

Eman

Last Name

Farid

MiddleName

Zein Elabdein

Affiliation

Obstetrics and Gynecology department, Faculty of Medicine, Beni-Suef University, Egypt

Email

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City

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Orcid

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First Name

Hamada

Last Name

Abdel-wahed

MiddleName

Ashry

Affiliation

Obstetrics and Gynecology department, Faculty of Medicine, Beni-Suef University, Egypt

Email

-

City

-

Orcid

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First Name

Heba

Last Name

Hemida

MiddleName

Abdel-Aleem

Affiliation

Obstetrics and Gynecology department, Faculty of Medicine, Beni-Suef University, Egypt

Email

-

City

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Orcid

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Volume

3

Article Issue

1

Related Issue

30429

Issue Date

2022-01-01

Receive Date

2022-01-31

Publish Date

2022-01-01

Page Start

68

Page End

83

Print ISSN

2682-4396

Online ISSN

2682-440X

Link

https://ejmr.journals.ekb.eg/article_216583.html

Detail API

https://ejmr.journals.ekb.eg/service?article_code=216583

Order

6

Type

Original Article

Type Code

1,224

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Research

Publication Link

https://ejmr.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023