This study aims to study the level of Vaspin and CRP in the serum of psoriatic patients as compared to normal control persons and to correlate their levels with the severity of the disease. Methods: 30 psoriasis patients as cases vs 30 normal patients as control were tested for CRP and Vaspin correlating the results with the Psoriasis Severity Index PSI. Results: There was a highly statistically significant difference between cases and controls regarding their VASPIN and CRP levels (P-value<0.001). in cases there was a significant positive moderate linear correlation between CRP and PASI. There was a significant strong negative linear correlation between the VASPIN and the PASI score (P-value=0.009), showed that at a cut off 75.6 of vaspin predicted that the patient had no psoriasis with 100% sensitivity and 75.6% specificity. Conclusions: CRP and Vaspin could be used as markers to assess the severity of the disease and treatment response.