The goal of this study was to detect the level of CXCL10 in the serum of  the vitiligo patients as compared to the normal control persons to investigate the possible role of CXCL10 in the pathogenesis of  this disease. The present study included 30 Egyptian vitiligo patients, their age ranged from (20 to 50 years). They were recruited fromDermatology outpatient clinic at Beni-Suef University hospital. Thirty unrelated apparent healthy controls with similar demographic (matched age and sex) were taken during the period from (1^st May 2018 to 1^st May 2019).5ml blood sample was taken from patients and controls and  was left to clot for 30 minutes then serum was separated  by centrifugation and kept frozen at -80c till analysis of CXCL10 by ELISA. The patients and controls were subjected to estimation of the serum level of CXCL10. The result of the study showed that  increased levels of CXCL10 in the vitiligo patients when compared to controls and the  patients in the progressive stage showed higher expression of CXCL10 than those in the stable stage,  suggesting a mechanistic  role of CXCL10 in vitiligo.