Background: RIFLE,KDIGO and AKIN has been used for diagnosis and grading of AKI (acute kidney injury).  The introduction of renal biopsy transformed the landscape for diagnosis and management of glomerular diseases. While the clinical classifications described above provide clinicians with a working-diagnosis, renal biopsy is typically required for definitive diagnosis. Objectives: Evaluation of incidence of acute kidney injury cases and their renal biopsies results in Beni-Suef university hospital. Patients and Methods: Our study include 63 Egyptian patients developed acute kidney injury presenting to internal medicine outpatient clinic and in patient of Beni-Suef University Hospital through one year from October 2018 to October 2019. Results: On histopathological examination renal biopsies, generallythe most common pathological finding in renal biopsies of patients with AKI in the study was focal segmental glomerulosclerosis 13(20%) these  result  was approved by followed by global glomerulosclerosis9(14%), Lupus nephritis IV 8(13%), acute tubular injury, diabetic nodular glomeruloscelerosis, Membranous N each one 4(6%). In diabetic group (7) the commonest pathology detected was Diabetic nodular glomeruloscelerosis 4(36%)with marked Interstitial fibrosis and tubular atrophy (IFTA). In hypertensive patients(29) the commonest pathology detected was Global GS8(28%) then Focal segmental glomeruloscelerosis6(20%). In SLE group (12) Lupus nephritis class VI 6(50%) followed by Lupus nephritis class III 4(33%).In apparent healthy patients the predominant pathology was Focal segmental glomeruloscelerosis26%followed by Global GS18.5%followed by membranous nephropathy (14.8%).