Patients seek therapeutic environments to receive the best medical care aiming fast recovery. Indoor design of the therapeutic environment is essential in creating a comfortable environment reducing the patient's isolation, distracting him from its disease, evoking positive feeling and helping his rapid recovery. The problem of research: have the indoor design and furniture of any therapeutic environment an impact on the psychological, physical, and cognitive health of patients and health care workers? The aim of the research: Reveals the factors of the indoor design and their effects in therapeutic environment that can make a great difference in the patients' and the health care workers' health and wellbeing.This study illustrated the factors of the indoor therapeutic environment that should be embedded in the design to achieve the needed results. The factors are the connection to nature, enhancing social supports, stimulating interior design features. Results:These factors affect positively the patient's physical, psychological health. This can help in improving their health and wellbeing and influencing the human behaviors, actions, allowing interactions between patients, families as well as hastening the patients' recovery. These factors also affect the health care workers, helping in improving their performance, productivity. The research proposed integration of those factors in the indoor design of a dental clinic for children to satisfy patient's relaxation and comfort and create a welcoming and friendly environment.