The purpose of the present research is to study the effect of textile structure (Coverage factor and the type of fabrics) on the comfort properties (breathability) and protection properties (resistance to fluid permeability and pores size). Where the problem with this research in lies in the lack or scarcity of research that dealt with the properties of comfort and protection, especially in fabric masks, and the experimental approach was used to reach the best results . Whereas, woven and knitted fabrics were used in the research samples. The Results of air permeability (breathability) showed that the textile structure has a great impact on the breathability property of both woven and knitted fabrics, as the higher the density of the threads at a certain limit in the warp and weft directions in woven fabrics and the number of rows and columns in knitted fabrics, the air permeability and breathability decreased. The results showed that the cloth mask made of knitted fabrics is better than the cloth mask made of woven fabrics in terms of comfort and protection properties. The reason of respect are knitted fabrics better than woven fabrics when used to make cloth masks Based on the results given in the research, the two-layer cloth masks made of knitted fabrics are better in the comfort properties of breathable, expressed in air permeability, according to the technical requirements issued by the Egyptian Ministry of Industry and Trade, as well as according to the standard specification. Also, masks made of knitted fabrics were better than masks made from woven fabrics in terms of protection properties represented in the size of pores as well as resistance to spray permeability, expressed by the fabrics' resistance to fluid permeability under hydrostatic pressure according to the standard specification.