Use of biochar and nitrogen application timing might be an effective strategy to ‎improve soil properties and increase wheat yield, especially in sandy soils. Giza 171 cultivar exhibited uppermost grain yield, almost yield attributes, nitrogen uptake efficiency (total-NUpE) and NUE followed by Shandwel 1. Biochar application at 6 Mg ha-1 significantly increased grain yield and almost yield attributes, total-NUpE and NUE compared with the control treatment. Adding N fertilizer at T2 or T3 had greatly improved grain yield and yield attributes and nitrogen use efficiencies comparing with T1 treatment. The interaction between N application timing at T2 and application of 6 Mg biochar ha-1 produced the maximum grain yield (7.23 Mg ha-1) and NUE (55.37 kg kg-1) when Giza 171 was used. Path coefficient analysis showed that spike length and number of spikes m-2 had exerted positive and high direct effect on grain yield of wheat (0.343 and 0.436), while flag leaf area and number of fertile spikeletes spike-1 had positive but moderate direct effect on wheat grain yield (0.280 and 0.201).