Population increase represents one of the most serious huge problems that trouble the Egyptian economy and impede development in all fields. The period (2000-2018) witnessed the growth rate of the consumption side of food commodities reach about 5%, compared to about 3% for the production side, which negatively affected the value and size of food commodities. The food gap, the high gap in the national and agricultural trade balance, and then the increase in dependence on the global market in providing our main food needs. Despite the efforts made to reduce this problem, the population growth rate is still high, hence the problem in studying the impact of population growth on National economic variables in Egypt, during the period (2000-2018). The results confirmed the existence of a positive, statistically confirmed relationship between the population as an independent variable in one million people and the study variables as dependent variables, as the increase in the population in Egypt by about one million leads to an increase in national income, national consumption, gross domestic product, real national investments, national imports and the government agreement amounted to LE. 83.9, 123.3, 33.4, 3.7, 123.3, and 29.1 billion, respectively. The results of the double logarithmic picture also indicated that increasing the population by about 10% increases the values ​​of these variables by about 54%, 70%, 38%, 30.1%, 66%, 75% for the same variables, and in the same order during the period (2000-2018). The research recommends increasing the volume of investments directed to national and agricultural projects with the development of programs to reduce the population problem.