This study was carried out at the farm of Faculty of Environmental Agricultural Sciences, Arish University, El-Arish, North Sinai, Egypt (31⁰ 08^'  40.3^̏ N, 33⁰ 49^ˋ 37.2̏ E), during 2016/2017 and 2017/2018 seasons. The aim of this study is to evaluate the response of three quinoa genotype (Giza 1, Danish KVL3704 and Misr 1) to three irrigation intervals. A split plot design with three replicates using Randomized Complete Block Design (RCBD) was performed. Three irrigation intervals used were [irrigation every (3days (I1), 6 days (I2) and 9 days (I3)[. Results showed that water stress caused a significant reduction in all studied traits except for 1000 -seed weight and carbohydrates content. Increasing irrigation intervals from 3 to 9 days decreased No. of panicles per plant from 13.62 to 9.68 in 2016/2017 season and from 16.29 to 10.53 in 2017/2018 season. Increasing irrigation intervals from 3 to 9 days decreased protein content (%) by (15.11%) in 2016/ 2017 season and (15.95 %) in 2017/2018 season.