Skeletal muscle can adopt to different chronic metabolic changes, such as regular exercise activities. Tae Bo (Total Awareness Excellence Body Obedience), includes aerobic and high intensity exercises with high synchronization regulatory modules leading to high improved upward and forward capacity, trunk and thigh elasticity, agility, synchronization and performance efficiency. Glycogen is the storage form of carbohydrate degraded to generate ATP during increased energy demand in exercise and re-synthesized during recovery. The initiation of glycogen synthesis is provided by a self-glucosylation of a protein self extracting enzyme glycogenin under the control of insulin and blood glucose levels. Post-exercise high glycaemic index carbohydrates intake favor glycogenin-1 activity. As far as our knowledge, there is no researches investigated blood glycogenin-1 response to Tae Bo exercise either acute or chronic. Thirty female students from the faculty of physical education for girls, Zagazig University, grade two were constituted subjects of this study. They were subjected to a Tae Bo training program for 12 weeks. Their physical measurements and blood glycogenin-1, insulin and glucose were assayed and correlated. Results revealed significant improvement in all physical measurements with increased response of post exercise blood levels in glycogenin-1 and insulin with administration of post-exercise high glycemic index drinks. It is concluded that training Tae Bo program with post exercise high glycemic index carbohydrate intake increase the physical efficiency with improved high performance.