The effective rehabilitation and prevention of HMSI of football playershave been challenging prepositions. In this article, we have shown a full recovery of for the Egyptian football playersfollowing a proposed specific rehabilitation program consisting of football-specific drills,high intensity interval anaerobic training, agility exercises with ball,complex exercises with ball, games skills exercise, and small games with the team. This study involved a deliberately chosen subject group of 18 players with HSMI who have been subjected to a specific rehabilitation programs described herein this work. Causes of HSMI were most frequent (44.44%) in sprinting-and-stop, and sprinting-and-make 3-4 steps, followed by acceleration (27.8%). Less frequent causes are plant-and-kick and slip-and-fall which were of equal frequency (11.1%). Stretching was the least frequent causes (5.6%) among all causes in this study. Applying the described specific rehabilitation program over three Phases, I, II, and III took 24-61 days according to the severity of injury. The time taken for implementing Phase I and II averaged 31.5±7.5days, whereas the time taken for implementing Phase III averaged 50.5±10.5.Progressive games with the team was essential inthe prevention re-injury mechanism of HMSI andinhelping players return to their previous level of the functional profile without putting them at risk for future injury. We believe that the success of the safe return to competitions does not depend on the length or short duration of rehabilitation, but the efficiency of the program in restoring motor functions that have been affected, according to the degrees of injury. The results of this study provide evidence that the risk of re-injury can beminimized or even eliminated by utilizing rehabilitation strategies that incorporate neuromuscularcontrol exercises and eccentric strength training, combined with objectivemeasures to assess musculotendon recovery and readiness to return to competitions.