ABSTRACT
Nephrotoxicity refers to kidney dysfunction or kidney damage that is
associated with an overload of drugs or xenobiotic. Agents with recognized
nephrotoxicity include molds and fungi, cancer therapeutics such as
cisplatin. In this study determine of the protective effect of strawberry leaves
against nephrotoxicity of male rats was evaluated. Thirty five adult male
albino rats (Sprague-Dawley strain), weighing about (150±10g) were
divided randomly into seven groups (5rats of each) as follow; -ve and +ve
control groups which fed on basal diet. Groups 3 and 5 fed on basal diet
supplemented with 5% and 10% strawberry leaves powder (SLP),
respectively. Groups 4 and 6 were orally administered with 5% and 10%
strawberry leaves water extract (SLWE), respectively. Also group 7was
orally administered with 50ml of diluted silymarin /Kg body weight of rats.
At the end of the experiment 28 days +ve control and groups 3-7 were
intraperitoneally injected with a single dose of cisplatin 5mg/kg of body
weight for four days. Rats were weighed daily and feed intake and feed
efficiency ratios were calculated. At the end of the experimental period rats
were sacrificed and serum was collected for biochemical analysis. The result
showed that SLP and SLWE improing serum blood lipids and markers of
kidney function and liver function as compared to the positive control group,
decreased malondialhyde (MDA) level and increased the activity of
antioxidant enzymes, glutathione (GSH) in the nephrotoxic rats. The high
concentration of SLP and SLWE ameliorated histopathological and
biochemical alterations that caused by cisplatin administration. According to
above findings this research recommended that a strawberry leaf has a
potential to be used as a functional health food ingredient with beneficial
effects on kidney damage.