ABSTRACT This study was carried out to investigate the effects of virgin coconut and sesame oils on the lipid profile and glucose level of diabetic male rats. Fifty-six adult male albino rats of the Sprague Dawley strain were divided into 8 groups. The administration, of alloxan (150 mg/kg BW) was done only once intraperitoneally for the groups from 2 - 8 to induce diabetes. After the hyperglycemia appeared, groups 3 – 8 were treated with 5 and 10 % virgin coconut oil, 5 and 10 % sesame oil, 5+5% and 2.5+2.5% of oils mixture for six weeks. The mean values of feed intake, body weight gain and feed efficiency ratio were improved in all tested groups except group 8 which was fed 2.5% virgin coconut+2.5% sesame oils mixture when compared with the + ve control group. While biochemical parameters such as insulin level, glucose level, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein (TP), and albumin, creatinine, urea, total cholesterol, triglycerides (TG), high density lipoprotein (HDL), very low-density lipoprotein (VLDL), low density lipoprotein (LDL), catalase and malondialdehyde (MDA) were improved compare with the + ve control group. According to the above findings this research recommended that usage of virgin coconut oil, sesame oil and 5% virgin coconut 5% sesame oils mixture had beneficial effects on diabetes. So more scientific researches must be done on this oils treatment effects on human beings.