ABSTRACT
Chronic kidney disease (CKD) is a worldwide public health
problem. Oxidative stress is the causative factor for a wide variety of
diseases, including CKD. Medicinal plants used in the management of
CKD are effective in renal detoxification and reduce the effects of
dialysis treatment. This work was conducted to investigate the effect of
aqueous extract of sage (Salvia Officinal) and marjoram (Origanum
Majoranum) on End Stage of Chronic Kidney patients under dialysis.
The experiment was carried out on sixty patients (40-50 years old),
diagnosis based on detailed clinical history, clinical examination and
other relevant biochemical investigations. The patients were divided into
6 groups (each group contain 10 CKD patients treated with (hemodialysis
and regular medical treatment for 3 months) as followed: positive control
patients were treated with regular medical treatment, other patients
consumed aqueous extracts of (5g sage, 5g marjoram, 10g sage, 10g
marjoram, mixture of 5g sage + 5g marjoram and mixture of 10g sage +
10g marjoram) twice today respectively. Results illustrated that the
aqueous extract of marjoram or sage are rich in antioxidants components
(Phenolic acids, Flavonoids, Oxygenated monoterpenes, Diterpenoids
and Triterpenes), antioxidant capacity and phenolic content. Results
clarify that glomerular filtration rate (GFR) increased, while erythrocyte
sedimentation rate (ESR) and C-reactive protein (CRP) significantly
decreased (P