Abstract
Coffee (Coffea L.) is the world's beloved drink that is the most
regularly consumed caffeine-containing beverage. It contains a complex
mixture of chemicals that provide important amounts of chlorogenic acid
and caffeine, which associated with many health benefits. The aim of the
present study was to investigate the protective effects of conventional,
decaffeinated coffee, green coffee and Arabic coffee extract on rats with
induced acute liver toxicity. Thirty six adult male albino rats (Sprague-
Dawley strain), weighing about (180±10 g) were divided randomly into
two main groups as follow: the first group (-ve control= 6 rats) was fed
on basal diet. The second group (30 rats) were divided into 5 subgroups
from subgroup 1 to subgroup 5. Subgroup 2 (+ve control) fed on basal
diet. Subgroups 2 and 5 were given the same dose of extracts 2ml/rat of
Conventional, Decaffeinated, Arabic and Green coffee, respectively.
After 6 weeks, subgroups from (1-5) were injected with one dose of
CCl4. At the end of the experimental period (6 weeks), rats were scarified
and serum was collected to determine biochemical analysis. The results
showed that the administration of CCl4 resulted in significant elevation in
serum activities of aspartate aminotransferase (AST) alanine
aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin
whereas serum total proteins albumin and globulin were significantly
reduced, along with significant elevation of malondialdehyde level
(MDA) and significant depletion in the level of reduced glutathione
peroxidase (GPX) compared with negative control. Treatment with
extracts of coffee prior to CCl4 produced protective effects and
attenuated these biochemical changes. The protective effects of extracts
of coffee were more pronounced for the Arabic coffee. It be concluded
that coffee beans exhibited hepatoprotective actions along with the
restoration of lipid profile in acute liver injury animal models.