ABSTRACT
The use of traditional medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. Therefore, the aim of the present study was to investigate the effect of Golden Berry (Physalis peruviana) fruits and its peels on acute hepatotoxicity with diabetes. Thirty six adult male rats were classified into 6 groups (6 rats each), Group (1), were fed on basal diet (control negative group). Rats (n=30) were injected by single intraperitoneal freshly prepared Streptozotocin (60 mg/kg b.wt.), these Animals were randomly enrolled into five groups as following: Group (2), diabetic rats were fed on basal diet (control positive group). Groups (3 and 4), diabetic rats were fed on basal diet supplemented with 5% and 10% dried golden berry fruit respectively. Group (5 and 6), diabetic rats were fed on basal diet supplemented with 5% and 10% dried peel of golden berry, respectively. All rats except control negative will be subcutaneous injected by carbon tetrachloride (Ccl4), twice at the end of experimental (4 weeks) feeding period to induce acute hepatotoxicity .
The results of the current study showed that basal diet supplemented with dried golden berry fruit or golden berry peels at the two studied level (5% and 10 %) caused a significant decrease (P<0.05) in the elevate level of serum glucose, urea, uric acid, creatinine, triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels, and significantly increased (P<0.05) the concentrations of high density lipoprotein and insulin activity as compared to the control diabetic rats. No statistical changes among the treated groups for all parameters were observed. It could be concluded that, golden berry fruit and peels improve the abnormal glucose metabolism, hyperlipidemia and increase insulin secretion as well alleviate hepatotoxicity associated with diabetes. Therefore, Golden berry and its peel might be used to treat diabetic patients and prevent diabetes complications such as hepatotoxicity.
Egypt. J. of Appl. Sci., 35 (11) 2020 158-