ABSTRACT
Nowadays, tend to use synthetic drugs to lower serum liver functions and glucose level in diabetic patients is gradually decreased because of their related side effects, as well as a progression of drug resistance. In this regard, tend to use of medicinal plants has been doubled. Therefore, the aim of the present study was to investigate the effect of Banana (Musa Balbisiana) fruits and its peels on acute hepatotoxicity with diabetes. Thirty six adult male rats were classified into 6 groups (6 rats each), Group (1), were fed on basal diet (control negative group). Rats (n=30) were injected by single intraperitoneal freshly prepared Streptozotocin (60 mg/kg b.wt.), these Animals were randomly enrolled into five groups as following: Group (2), diabetic rats were fed on basal diet (control positive group). Groups (3 and 4), diabetic rats were fed on basal diet supplemented with 5% and 10% dried banana fruit respectively. Group (5 and 6), diabetic rats were fed on basal diet supplemented with 5% and 10% dried peel of banana fruit, respectively. All rats except control negative will be subcutaneous injected by carbon tetrachloride (Ccl4), twice at the end of experimental (4 weeks) feeding period to induce acute hepatotoxicity .
The results of the current study showed that basal diet supplemented with dried banana fruit or banana peels at the two studied level (5% and 10 %) caused a significant decrease (P<0.05) in the elevate level of serum glucose, urea, uric acid, creatinine, triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels, and significantly increased (P<0.05) the concentrations of high density lipoprotein and insulin activity as compared to the control diabetic rats. No statistical changes among the treated groups for all parameters were observed. The present study demonstrates that banana fruit and its peel has hepatoprotective, hypoglycemic effects against diabetic hepatotoxic rats .