ABSTRACT
This study was carried out to investigate the effect of curcumin,
ginger and their combination on serum kidney functions of rats with
acute kidney failure. Rats were given intramuscular injections by
glycerol to induce acute kidney failure. After the period of adaptation,
rats were divided into two main groups. The first main group (n=6) was
fed on the basal diet during the experimental period as a negative control
group (-Ve). The second main group (n=24) was injected with one dose
of 50% glycerol (10 ml/kg B.Wt.) in their hind limbs to induce acute
renal failure. These rats were divided into 4 subgroups, as follows:
Subgroup (1): Rats with acute kidney disease (AKD rats) were fed on
basal diet as positive control group (+Ve). Subgroups (2 and 3): AKD
Rats were fed on basal diet supplemented with 2.5% dried Turmeric and
2.5% dried Ginger, respectively. Subgroup (4): AKD Rats were fed on
basal diet supplemented with 2.5% mixture of ginger and turmeric at
ratio (1:1).
The results displayed that, supplementation with dried ginger or
turmeric at 2.5% significantly improved (P<0.05) kidney functions as
well as serum glucose, liver functions and lipid profile as compared to
positive control group. Moreover, the lowered body weight of rats with
acute kidney failure was increased due to supplementation with the tested
materials. The mixture of ginger and turmeric gave the highest
improvement of kidney functions and other tested parameters. It could be
concluded that, ginger and/or turmeric and their mixture are suitable for
alleviating the complications of acute kidney failure.