ABSTRACT The thermal decomposition of norephedrine hydrochloride was investigated by nonisothermal thermogravimetric analysis under nitrogen atmosphere at three heating rates 5,10,20^o Cmin^-1, where the determination of kinetic triplet (activation energy, pre-exponential factor, and reaction model), was the key objective. The activation energy was determined using different isoconversional methods, Friedman, Flynn-Wall-Ozawa (FWO), Kissinger-Akahira-Sunose (KAS), and Tang. The pre-exponential factor was calculated using Kissinger’s equation; while the reaction model was predicted by comparison of z-master plot obtained from experimental values with the theoretical plots. Isoconversional methods revealed negligible variation of E_a with the conversion, showing that the nonisothermal decomposition process of norephedrine hydrochloride follows a single-step reaction. The kinetic triplet determined was, activation energy, E_a = 121.09 kJmol^-1, pre-exponential factor, A=5.39×10^-4 min^-1 and the reaction kinetic model follows Gintsling equation (three dimensional diffusion)                       D4 model , f(α) = 16321-خ±1/3-1"> ,   g(α) = 161-2خ±3-1-خ±23"> .