Beta
ManageSearchChatDiscover
258241

Intense intrafamilial transmission of HBV in a rural area in Egypt is a probable cause of non-response to vaccination: A cross-sectional-seroprevalence-community-study.

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Infectious Diseases

Abstract

Background: Worldwide, the prevalence of hepatitis B virus (HBV) infection is decreasing particularly in the vaccinated population. However, there are foci of increased transmission particularly in localized communities and within families. Objective: This study aimed at identifying HBV infection status among family members (FMs) of a cohort of HBsAg positive index cases (ICs) living in a village near Ismailia City, North-East Egypt. Design and participants: The study targeted ICs with chronic hepatitis B and their FMs. All were inquired for socio-demographic data, previous vaccination, kinship, and risk factors. All were tested for hepatitis markers and in HBcAb positive sera, HBV DNA and ALT were added. Results: The study included 96 participants including 14 ICs, 51 (53.1%) were females and 73 (76%) self-reported receiving hepatitis B vaccine after birth. Among 82 FMs, HBcAb was found in 49 (59.76%) of whom overt and occult HBV were diagnosed in 24 (49%) and 18 (36.7%). HBs Ag and HBcAb were more frequent in unvaccinated compared to vaccinated FMs; being 60.9% vs. 32.9% for HBsAg (p < /em>=0.017) and 91.3% vs. 57.5% for HBcAb (p < /em>=0.003). Among the FMs, active HBV were more related to male than female ICs (54.9% vs. 45.2%, p < /em>=0.73) while among children, it is more related to females more than male ICs (38.9% vs. 25%, p < /em>=0.33). In all HBsAg positive participants, HBeAg was negative and HBV DNA load was higher among female than male ICs (median 3500 vs. 2594.5 IU/mL, p < /em>=0.82). Conclusion: The study shows a high rate of HBV transmission among FMs of HBsAg carriers living in a remote area in North-East Egypt. Both overt and occult HBV infections were frequent despite previous vaccination

DOI

10.21608/mid.2022.150592.1349

Keywords

HBV, intrafamilial-transmission, OBV, Vaccination, Egypt

Authors

First Name

Nader

Last Name

Nemr

MiddleName

-

Affiliation

Department of infectious diseases, Suez Canal University

Email

nadernemr@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Rania

Last Name

Kishk

MiddleName

M.

Affiliation

Microbiology And Immunology Department, Faculty Of Medicine, Suez Canal University Round Road 4.5km

Email

raniakishk@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Mohamed

Last Name

Mandour

MiddleName

-

Affiliation

Clinical patholgy department, faculty of medicine, Suez canal University

Email

mohamed_mostafa@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Moustafa

Last Name

Ragheb

MiddleName

-

Affiliation

Endemic and infectious diseases department, Faculty of medicine, Suez Canal University, Ismailia, Egypt.

Email

moustafa_ragheb@med.suez.edu.eg

City

Cairo

Orcid

-

First Name

Hebatalla

Last Name

Mohamed

MiddleName

-

Affiliation

Department of occupational and environmental medicine, Faculty of medicine, Suez Canal University, Ismailia, Egypt.

Email

hebatalla.mohamed@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Eman

Last Name

Fahmy

MiddleName

-

Affiliation

Internal Medicine department, Faculty of medicine, Suez Canal University, Ismailia, Egypt.

Email

emanfahmy@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Mohamed

Last Name

Eida

MiddleName

-

Affiliation

Endemic and infectious diseases department, Faculty of medicine, Suez Canal University, Ismailia, Egypt.

Email

eidamohamed17@gmail.com

City

Ismailia

Orcid

-

First Name

Nageh

Last Name

Mahrous

MiddleName

Louis

Affiliation

Lecturer of Endemic and Infectious diseases, Faculty of Medicine, Suez Canal University

Email

dr_nageh_2010@yahoo.com

City

Ismailia

Orcid

0000-0003-1026-669x

Volume

3

Article Issue

4

Related Issue

37291

Issue Date

2022-10-01

Receive Date

2022-07-17

Publish Date

2022-10-01

Page Start

878

Page End

889

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 3_Issue 4_Pages 878-889.pdf

PDF . 375.9kB

Link

https://mid.journals.ekb.eg/article_258241.html

Detail API

https://mid.journals.ekb.eg/service?article_code=258241

Order

14

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Intense intrafamilial transmission of HBV in a rural area in Egypt is a probable cause of non-response to vaccination: A cross-sectional-seroprevalence-community-study.

Details

Type

Article

Created At

22 Jan 2023