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249386

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Infection prevention and control

Abstract

Background:: Vaccination compared to other measures is considered the most efficient and cost-effective strategy against hepatitis B virus (HBV) infection which decreases the incidence of both HBV infection and hepatocellular carcinoma. This study involved 179 children vaccinated against HBV during infancy, and aimed to assess the immune status against HBV among HBV vaccinated children in different age groups. Methods: Participants were chosen according to previously settled inclusion and exclusion criteria. Recruited participants' ages ranged from 9 months till 10 years who had received the full routine infancy vaccination course. Participants were divided according to age into three groups: group A ages from 9 months to less than 2 years of age (41 children 22.9%), group B ages from 2 years to less than 5 years (64 children 35.8%), and group C ages from 6 years to 10 years (74 children 41.3%). Serum levels of antiHBs were measured. Results: Out of 179 participants, there were 154 children (86%) seroprotected, while 25 children (14%) were not. Moreover, 100% of children under 3 years were seroprotected. Seroprotection rate under 5 years was 95.2%. While in group C seroprotection rate was 73%. Males showed a slightly higher seroprotection rate than females although statically insignificant. Conclusion: Universal hepatitis B vaccination shows excellent effectiveness in Egypt. Total seroprotection rate (86%) is higher than in previous local and global studies that may return to the recent implementation of birth dose in Egypt.

DOI

10.21608/mid.2022.145372.1327

Keywords

hepatitis B, HBV vaccine, Birth Dose, Universal Vaccination Program

Authors

First Name

Rasha

Last Name

Bakr

MiddleName

Ahmed

Affiliation

Department of Microbiology, Medical Research Institute, University of Alexandria, Egypt.

Email

mri.rasha.m.inf.microbiology19@alexu.edu.eg

City

Rashid

Orcid

-

First Name

Eglal

Last Name

El Sherbini

MiddleName

-

Affiliation

Medical Research Institute, Alexandria University Address: 165, Horreya Avenue,

Email

eglalsher@yahoo.com

City

Alexandria

Orcid

-

First Name

Aliaa

Last Name

Aboulela

MiddleName

Gamaleldin

Affiliation

Department of Microbiology, Medical Research Institute, University of Alexandria, Egypt

Email

aliaagamaleldin@alexu.edu.eg

City

-

Orcid

0000-0002-2923-1027

First Name

Mohamed

Last Name

Abougabal

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of medicine, University of Alexandria, Egypt.

Email

abougabal79l@gmaill.com

City

-

Orcid

-

First Name

Amel

Last Name

Elsheredy

MiddleName

-

Affiliation

Microbiology department, Medical Research Institute, Alexandria University, Egypt.

Email

amel.elsheredy@alexu.edu.eg

City

-

Orcid

0000-0001-6368-2596

Volume

3

Article Issue

4

Related Issue

37291

Issue Date

2022-10-01

Receive Date

2022-06-17

Publish Date

2022-10-01

Page Start

869

Page End

877

Print ISSN

2682-4132

Online ISSN

2682-4140

Link

https://mid.journals.ekb.eg/article_249386.html

Detail API

https://mid.journals.ekb.eg/service?article_code=249386

Order

13

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Details

Type

Article

Created At

22 Jan 2023