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207846

Small colony variants phenotype and biofilm formation: Implication in persistent <i>Staphylococcus aureus</i> infection

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Antimicrobial resistance
Medical microbiology

Abstract

Staphylococcus aureus survival strategy for persistence can be attributed to their metabolic versatility under unfavorable conditions by switching to small colony variants (SCVs) phenotype and forming biofilm; these attributes contribute to their widespread dissemination, difficulty to detect in routine microbiological screening and challenging eradication particularly in clinical setting, resulting to persistent nature of their infections. The SCVs can survive intracellularly, misinterpreted as  coagulase negative Staphylococcus aureus (CoNS) and down regulate some virulence factors. Biofilm formation provides protection against antibiotics and immune responses; the matrix serve as a physical barrier and transfer of resistant determinant via conjugation occur among the encased bacteria because of their proximity. Thus; SCVs and biofilm aid evasion of antibiotics and immune response resulting to persistent infection. Therefore, understanding the process associated with the ability of bacteria to persist could significantly aid in the development of a better therapeutic options that will ultimately reduce the risk of morbidity and mortality.

DOI

10.21608/mid.2021.103244.1205

Keywords

Persistent infection, Small colony variants (SCVs), biofilm formation, Staphylococcus aureus

Authors

First Name

Haruna

Last Name

Adamu

MiddleName

-

Affiliation

Department of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, Nigeria

Email

ajharuna1075@gmail.com

City

Zaria

Orcid

-

First Name

Abdulrahman

Last Name

Kasim

MiddleName

-

Affiliation

Department of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, Nigeria

Email

abdulrahmanclean34@gmail.com

City

Zaria

Orcid

-

First Name

Shitu

Last Name

Abdullahi

MiddleName

-

Affiliation

Department of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, Nigeria

Email

shitabeh91@gmail.com

City

Zaria

Orcid

-

First Name

Patrick

Last Name

Shaibu

MiddleName

Yila

Affiliation

Department of Nursing, College of Nursing and Midwifery, Gombe State, Nigeria

Email

spatrickyila@gmail.com

City

Gombe

Orcid

-

Volume

3

Article Issue

3

Related Issue

35766

Issue Date

2022-08-01

Receive Date

2021-10-28

Publish Date

2022-08-01

Page Start

668

Page End

674

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 3_Issue 3_Pages 668-674.pdf

PDF . 316.8kB

Link

https://mid.journals.ekb.eg/article_207846.html

Detail API

https://mid.journals.ekb.eg/service?article_code=207846

Order

18

Type

Review Article

Type Code

1,160

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Small colony variants phenotype and biofilm formation: Implication in persistent <i>Staphylococcus aureus</i> infection

Details

Type

Article

Created At

22 Jan 2023