ManageChatDiscover
233202

Microbiological profiles of neonatal sepsis in northern Egypt

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background:This study aimed at analyzing the microbiological profile of neonatal sepsis in Egypt and to determine the antibiotic susceptibility patterns of the isolated microorganisms. Methods: Two thousand and four hundred blood samples were collected from neonates showing symptoms suggestive of septicemia, inoculated into BACT/ALERT culture bottles. Positive blood culture samples were identified and tested for antimicrobial susceptibility. Results: Among the neonates included in our study, 457 (19%) neonates were positively diagnosed with sepsis. early onset neonatal sepsis (EOS) was detected in 181 (39.6%), while late-onset neonatal sepsis (LOS) in 276 (60.4%) cases. Klebsiella pneumoniae was the most commonly isolated microorganism. Staphylococcus aureus and Enterococcus spp. were the most common isolated Gram-positive bacteria. Candida spp. was more encountered in LOS.An alarming feature of the present study is the high incidence of multidrug resistant microorganisms (65%). Among Gram negative isolates (56%) of were extended spectrum beta-lactamase (ESBL) producers and (70.5%) were carbapenem resistant. In Gram positive bacteria, resistance to methicillin in S. aureus and coagulase negative staphylococci were detected in (50%) and (41%) of isolates respectively. Additionally, 17% of Enterococcus isolates were vancomycin resistant. Coclusion: Our bacteriological profile of neonatal sepsis showed that Gram negative bacteria represented the majority of isolates. Klebsiella pneumoniae was the predominant isolate. In our study, both EOS & LOS share a nosocomial infection profile, as high antimicrobial resistance was observed among our isolates. The susceptibility profiles of the isolates may urge for the change of the current used empirical therapies.

DOI

10.21608/mid.2022.129600.1265

Keywords

Neonatal sepsis, Early onset sepsis, Late onset sepsis, Multi drug resistance, BACT/ALERT

Authors

First Name

Ahmed

Last Name

Gaballah

MiddleName

Hassan

Affiliation

Microbiology Department, Medical Research Institute, Alexandria University

Email

ahmed.gaballah@alexu.edu.eg

City

Lyon

Orcid

-

First Name

Sherine

Last Name

Shawky

MiddleName

-

Affiliation

Department of Microbiology, Medical research institute, Alexandria university

Email

sherine.shawaky@alexu.edu.eg

City

Alexandria

Orcid

-

First Name

Ahmed

Last Name

Amer

MiddleName

Noby

Affiliation

Microbiology and immunology, faculty of Pharmacy, Pharos university

Email

ahmed.amer@pua.edu.eg

City

-

Orcid

0000-0003-3610-4592

Volume

3

Article Issue

3

Related Issue

35766

Issue Date

2022-08-01

Receive Date

2022-03-26

Publish Date

2022-08-01

Page Start

645

Page End

656

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 3_Issue 3_Pages 645-656.pdf

PDF . 307.4kB

Link

https://mid.journals.ekb.eg/article_233202.html

Detail API

https://mid.journals.ekb.eg/service?article_code=233202

Order

16

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Microbiological profiles of neonatal sepsis in northern Egypt

Details

Type

Article

Created At

22 Jan 2023