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214861

Sequencing of Rhinoviruses in Egyptian children with respiratory tract infections

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Medical virology

Abstract

Background: Human rhinoviruses (HRV) are one of the most common causes of upper respiratory tract infections among young children.  Human rhinoviruses have  a wide genetic diversity. They include three different species A, B and-C. Acute Respiratory Infection (ARI) is considered to be  an important  cause of morbidity and mortality in neonates and children. Aim of the study:  To  detect  the common  subtypes of circulating HRV among Egyptian children with respiratory infections for  further epidemiological characterization. Methods: We enrolled 161 children admitted to Ain Shams Pediatric University Hospital complaining of respiratory tract infections.  Human rhinoviruses  were detected by RT-PCR. Sequencing of HRV was done based on viral proteins (VP4-VP2) genomic region analyses by RT-PCR. Results: HRV were detected in 54 cases (33.5%)with respiratory tract infections.Sixty-five (65) % of detected HRV was in children aged 5-10 years. Molecular sequencing  showed high prevalence of HRV-C (67%) followed by HRV-A (33%). Conclusion:  This study is from the first few studies that revealed diversity of HRV in Egypt. Different phylogenetic studies are needed to evaluate their diversity and to trace their spread and epidemiological origin.

DOI

10.21608/mid.2022.113594.1222

Keywords

Rhinoviruses, Acute respiratory tract infections, RT-PCR

Authors

First Name

Mona

Last Name

Khattab

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

monaadelhkattab@med.asu.edu.eg

City

Cairo- Egypt

Orcid

0000-0002-0689-2543

First Name

Shereen

Last Name

Taha

MiddleName

El Sayed

Affiliation

Department of Medical Microbiology and Immunology Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

cherrytaha73@yahoo.com

City

-

Orcid

-

First Name

Fatma

Last Name

Abd El Aziz

MiddleName

Mohamed

Affiliation

Department of Medical Microbiology and Immunology Faculty of Medicine, Misr University for Science and Technology, Giza, Egypt

Email

fatmaabdelaziz35@gmail.com

City

-

Orcid

-

First Name

Nancy

Last Name

Abu Shady

MiddleName

Mohamed

Affiliation

Department of Pediatrics Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

nancyabushady@yahoo.com

City

-

Orcid

-

First Name

Rachel

Last Name

Scheuer

MiddleName

-

Affiliation

Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands

Email

scheuerrachel@gmail.com

City

-

Orcid

-

First Name

Ron

Last Name

Fouchier

MiddleName

-

Affiliation

Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands

Email

ronfoucheir@yahoo.com

City

-

Orcid

-

First Name

Ali

Last Name

Zaki

MiddleName

Mohamed

Affiliation

Department of Medical Microbiology and Immunology Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

azaki53@hotmail.com

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

32908

Issue Date

2022-05-01

Receive Date

2021-12-09

Publish Date

2022-05-01

Page Start

279

Page End

285

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 3_Issue 2_Pages 279-285.pdf

PDF . 495.0kB

Link

https://mid.journals.ekb.eg/article_214861.html

Detail API

https://mid.journals.ekb.eg/service?article_code=214861

Order

6

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Sequencing of Rhinoviruses in Egyptian children with respiratory tract infections

Details

Type

Article

Created At

22 Jan 2023