204984

Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Infectious Diseases
Medical virology

Abstract

Aim: Aim is to depict suggestive urine and stool parameters in asymptomatic suspected contact children living with COVID-19 infected adults. These parameters will facilitate identifying  children who deserve the confirmatory diagnosis of COVID-19 by PCR test.  Methods: Study was conducted in the National Hepatology and Tropical Medicine Research institute (NHTMRI) Cairo, Egypt. It included 66 mild COVID-19 adult patients (group1) and their 82 asymptomatic contact children (group 2). Results:  In group 1, both C reactive protein (CRP) and D-dimer levels were significantly high. C reactive protein was significantly positively correlated with urinary microalbumin> 30, albumin/ creatinine ratio and urine pus >10 cells / HPF and significantly negatively correlated with vitamin C. D-dimer was significantly negatively correlated with vitamin C. In group 2, CRP and D-dimer were significantly negatively correlated with urine specific gravity (SG), urinary vitamin C. CRP was significantly negatively correlated with stool pus > 10 cells/ HPF, while D-dimer was significantly positively correlated with stool occult blood.   Receiver Operating Curve (ROC) analysis revealed that urine SG showed the highest area under the curve (AUC); 0.859, 0.96, sensitivity of 100%, 100% and specificity of 71.8%, 77.8% with reference to D-dimer and CRP; respectively. Conclusions: In contact children of adult COVID-19 proved infection, urine SG, stool occult blood and stool pus > 10 cells/ HPF can be feasible tool for suspected COVID-19 infection, based on its results COVID-19 PCR request can be an imperative option to confirm the diagnosis; particularly in developing countries where detection of COVID -19 by PCR is not readily feasible.

DOI

10.21608/mid.2021.102294.1204

Keywords

COVID19, urine, stool, children

Authors

First Name

Fetouh

Last Name

Hassanin

MiddleName

-

Affiliation

Clinical Pharmacy department (pediatrics), Misr International University, Cairo, Egypt

Email

fhassanin@aim.com

City

Cairo

Orcid

0000-0001-7668-6211

First Name

Azza

Last Name

Abbas

MiddleName

-

Affiliation

Medical Parasitology, Immunology and Microbiology Department, National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt

Email

azzahas17@gmail.com

City

-

Orcid

-

First Name

Elshahat

Last Name

Alaa

MiddleName

-

Affiliation

Medical Parasitology, Immunology and Microbiology Department, National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt

Email

elshahat_alaa@yahoo.com

City

Cairo

Orcid

-

First Name

Mona

Last Name

Schaalan

MiddleName

-

Affiliation

Clinical Pharmacy department (pharmacy), Misr International University, Cairo, Egypt

Email

mona.schaalan@miuegypt.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Rabea

MiddleName

-

Affiliation

Department of Pediatric Gastroenterology, National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt

Email

egyrabea2012@gmail.com

City

Cairo

Orcid

0000-0002-5556-4124

Volume

3

Article Issue

1

Related Issue

29888

Issue Date

2022-02-01

Receive Date

2021-10-12

Publish Date

2022-02-01

Page Start

36

Page End

47

Print ISSN

2682-4132

Online ISSN

2682-4140

Link

https://mid.journals.ekb.eg/article_204984.html

Detail API

https://mid.journals.ekb.eg/service?article_code=204984

Order

5

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Details

Type

Article

Created At

22 Jan 2023