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208148

Evaluation of the predictive value of C-reactive protein, interleukin-6 and their derived immune-inflammatory indices in COVID-19 Egyptian patients

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases
Medical virology

Abstract

Background: In coronavirus disease 2019 (COVID-19), finding sensitive biomarkers is critical for detecting severe cases early and intervening effectively. Aim of the work:  To compare and evaluate the value of pretreatment c-reactive protein (CRP), interleukin-6 (IL-6), and their derived immune-inflammatory indices (CRP/albumin (CRP/alb), lymphocyte/CRP (L/CRP), and lymphocyte/IL-6 (L/IL-6)) in the prediction of COVID-19 severity and in-hospital mortality. Methods: This cross-sectional study included 85 confirmed COVID-19 patients, their complete blood count with differential, as well as albumin and IL-6 levels on the day of their hospital admission, were assessed and compared. We followed all patients till their in-hospital death or discharge from the hospital. Results: On admission levels of CRP, IL-6, and CRP/alb were significantly higher (p < /em>=0.001) in severe patients and non-survivors, but L/CRP and L/IL-6 were significantly lower (p < /em>=0.001) compared to non-severe patients and non-survivors. CRP/alb and L/CRP at cut-offs of 1.65 and 260.86, respectively, were the best predictors for COVID-19 severity, while IL-6 and L/IL-6 at cut-offs of 120 pg/ml and 5.40, respectively, were the best predictors for COVID-19 in-hospital mortality. IL-6 was an independent risk factor associated with severe disease development (odds ratio (OR): 1.033; 95% confidence interval (CI): 1.002-1.066). Conclusions: Pretreatment levels of CRP, IL-6, and their derived indices should be included in the diagnostic work-up of COVID-19 to determine the severity and predict the outcome.

DOI

10.21608/mid.2021.103331.1207

Keywords

COVID-19, CRP, Interleukin-6, mortality, severity

Authors

First Name

Sara

Last Name

Taha

MiddleName

I.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr_sara_ib@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-8224-8701

First Name

Aalaa

Last Name

Shata

MiddleName

K.

Affiliation

Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University, Cairo,Egypt.

Email

aalaashata@yahoo.com

City

Cairo

Orcid

-

First Name

Eman

Last Name

El-Sehsah

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt

Email

emanalsahsah@gmail.com

City

Mansoura

Orcid

-

First Name

Shaimaa

Last Name

Fouad

MiddleName

H.

Affiliation

Department of Internal Medicine / Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

shaimaahani@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4052-9454

First Name

Aya

Last Name

Moussa

MiddleName

H.

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ayahisham@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4680-2204

First Name

Shaimaa

Last Name

Abdalgeleel

MiddleName

A.

Affiliation

Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt.

Email

shaimaa.abdalgeleel@nci.cu.edu.eg

City

Cairo

Orcid

0000-0003-0994-7703

First Name

Nouran

Last Name

Moustafa

MiddleName

M.

Affiliation

Department of Basic Medical Science, Faculty of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia &amp; Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

nouran.m@dau.edu.sa

City

Saudi Arabia

Orcid

0000-0002-3956-1484

First Name

Mariam

Last Name

Youssef

MiddleName

K.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr.mariam_karam@hotmail.com

City

Cairo

Orcid

0000-0003-2075-3889

Volume

3

Article Issue

1

Related Issue

29888

Issue Date

2022-02-01

Receive Date

2021-11-05

Publish Date

2022-02-01

Page Start

13

Page End

23

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 3_Issue 1_Pages 13-23.pdf

PDF . 507.9kB

Link

https://mid.journals.ekb.eg/article_208148.html

Detail API

https://mid.journals.ekb.eg/service?article_code=208148

Order

3

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023