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118419

Contribution of XPERT MTB/RIF® in the diagnosis of pulmonary tuberculosis in Ziguinchor, Senegal

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Medical bacteriology

Abstract

Introduction ─ Multidrug-resistant tuberculosis is resistant to isoniazid and/or rifampicin. It is favored by poverty and infection with the human immunodeficiency virus. This retrospective, descriptive study aimed to determine the contribution of Xpert MTB/RIF® in the diagnosis of multidrug-resistant pulmonary tuberculosis in a semi-urban environment at the Peace Hospital of Ziguinchor in Senegal during the period from April 2015 to August 2019.
Methodology ─ The study is retrospective, descriptive and carried out in the laboratory of Ziguinchor Hospital de la Paix, in southern Senegal, from April 2015 to August 2019. All respiratory specimens were subjected to Ziehl-Neelsen-stained smear microscopy and Xpert MTB/RIF® testing.
Results ─ 180 samples, i.e. 6.4% were microscopy-negative but positive in Xpert MTB/RIF® testing. 32 patients (1%) are infected with rifampicin-resistant M. tuberculosis, against 29% of patients (798/2794) infected with susceptible strains.
Conclusion ─ Tuberculosis is not longer a “disease of the past". Having a high cost, Xpert MTB/RIF® testing must be associated with microscopy, which remains accessible in semi-urban areas and is easy to perform.

DOI

10.21608/mid.2020.43109.1063

Keywords

tuberculosis, resistance, Rifampicin, Xpert MTB/RIF®

Authors

First Name

Habibou

Last Name

SARR

MiddleName

-

Affiliation

Health Sciences Training and Research Unit, University of Ziguinchor, Laboratory and Infectious Diseases Department of the hospital PAIX of Ziguinchor, Senegal

Email

habibou10@live.fr

City

-

Orcid

-

First Name

Aissatou Ahmet

Last Name

NIANG

MiddleName

-

Affiliation

Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal

Email

niangaisatou@yahoo.fr

City

-

Orcid

-

First Name

Baidy

Last Name

DIEYE

MiddleName

-

Affiliation

Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal

Email

baidy.dieye@yahoo.fr

City

-

Orcid

-

First Name

Amadou

Last Name

DIOP

MiddleName

-

Affiliation

Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal

Email

amadoudioplaba@yahoo.fr

City

-

Orcid

-

First Name

Fatoumata

Last Name

DIALLO

MiddleName

-

Affiliation

Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal

Email

fafadialo@gmail.com

City

-

Orcid

-

First Name

Rokhaya

Last Name

DIAGNE

MiddleName

-

Affiliation

Health Sciences Training and Research Unit, University of Thies, Dakar, Senegal

Email

rodiagne1@yahoo.fr

City

-

Orcid

-

First Name

Seynabou

Last Name

LO

MiddleName

-

Affiliation

Health Sciences Training and Research Unit, Saint Louis University, Dakar, Senegal

Email

zeynaby78@hotmail.fr

City

-

Orcid

-

First Name

Kalilou

Last Name

DIALLO

MiddleName

-

Affiliation

Health Sciences Training and Research Unit, University of Ziguinchor, Laboratory and Infectious Diseases Department of the hospital PAIX of Ziguinchor, Senegal

Email

kalildiall@yahoo.fr

City

-

Orcid

-

First Name

Ahmad Iyane

Last Name

SOW

MiddleName

-

Affiliation

Faculty of Medicine, Pharmacy and Dentistry, Dakar, Senegal

Email

profisow3@gmail.com

City

-

Orcid

-

Volume

2

Article Issue

4

Related Issue

28168

Issue Date

2021-11-01

Receive Date

2020-09-07

Publish Date

2021-11-01

Page Start

690

Page End

696

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 2_Issue 4_Pages 690-696.pdf

PDF . 295.9kB

Link

https://mid.journals.ekb.eg/article_118419.html

Detail API

https://mid.journals.ekb.eg/service?article_code=118419

Order

12

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023