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Prevalence of anti-measles antibodies in infants from 0 to 9 months: case of three hospitals in the city of Douala (Cameroon)

Article

Last updated: 04 Jan 2025

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Tags

Medical virology

Abstract

Background: Measles is an acute infection, usually occurring in childhood, caused by a virus of the Paramyxoviridae family. Infants born to mothers immunized against measles benefit from the transplacental transfer of anti-measles antibodies of the IgG type, and are in principle protected against infection in the first months of life. Methods: A cross-sectional study was carried out on infants born at term and not vaccinated against measles, in three hospitals in the city of Douala (General Hospital, Gynaecologic Obstetrics and Pediatrics Hospital and Laquintinie Hospital). The qualitative and quantitative research of type G immunoglobulins in serum or plasma was carried out by the ELISA technique using the "Measles Virus IgGTM" kits, followed by a colorimetric reading. Sociodemographic and biological data were collected and analyzed.  Results: A total of 178 infants were recruited of which 54.5% were male. The average age was 3 months ± 2.6 and the most common age group was 0 to 1 month. Antibody levels ranged from 8 to 5,700 mIU/ml and 39.9% of infants had protective levels against measles. The presence of antibodies based on age was 81.1% in 0-1 months infants, 51.1% 1-3 months, and 8.2% 3-6 months, respectively. Only one of them was protected in the 6 to 9 month age group. We observed a significant association between infant age, maternal history of measles and the rate of protected infants.  Conclusion: The frequency of maternal antibodies in infants was low. Strategies should be put in place to strengthen the fight against this resurgent disease.

DOI

10.21608/mid.2020.45386.1071

Keywords

Maternal antibodies, infants, measles, protection rate, Douala

Authors

First Name

CECILE

Last Name

OKALLA

MiddleName

-

Affiliation

Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala. Laboratory of Clinical Biology General Hospital, Douala, Cameroon.

Email

cecileokalla@yahoo.fr

City

DOUALA

Orcid

0000-0003-2460-6712

First Name

DAVID

Last Name

DONFACK

MiddleName

-

Affiliation

Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon

Email

daviddonfack28@gmail.com

City

DOUALA

Orcid

-

First Name

CALIXTE IDA

Last Name

PENDA

MiddleName

-

Affiliation

Department of Clinical Sciences – Faculty of Medecine and Pharmaceutical Sciences – University of Douala – Cameroon

Email

idapenda@yahoo.fr

City

DOUALA

Orcid

-

First Name

HENRY

Last Name

ESSOME

MiddleName

-

Affiliation

Department of Surgery and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon.

Email

essometocky@yahoo.com

City

DOUALA

Orcid

-

First Name

DANIELE

Last Name

KOUM

MiddleName

-

Affiliation

Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon. Department of Surgery and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon. Pediatric Unit, Gyneco-obstetric and Pediatric Hospital, Doula, Cameroon

Email

dckedykoum@yahoo.fr

City

DOUALA

Orcid

-

First Name

EMMANUEL RODDY

Last Name

MENGUE

MiddleName

-

Affiliation

Laboratory of Clinical Biology, General Hospital, Douala, Cameroon

Email

remengue@outlook.fr

City

DOUALA

Orcid

-

First Name

ACHILLE

Last Name

CHUENGOUE

MiddleName

-

Affiliation

Laboratory of Clinical Biology, General Hospital, Douala, Cameroon

Email

ackil84@yahoo.fr

City

DOUALA

Orcid

-

First Name

DIEUDONNE

Last Name

ADIOGO

MiddleName

-

Affiliation

Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon

Email

d_adiogo@yahoo.fr

City

DOUALA

Orcid

-

Volume

2

Article Issue

4

Related Issue

28168

Issue Date

2021-11-01

Receive Date

2020-09-07

Publish Date

2021-11-01

Page Start

682

Page End

689

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 2_Issue 4_Pages 682-689.pdf

PDF . 373.1kB

Link

https://mid.journals.ekb.eg/article_119895.html

Detail API

https://mid.journals.ekb.eg/service?article_code=119895

Order

11

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Prevalence of anti-measles antibodies in infants from 0 to 9 months: case of three hospitals in the city of Douala (Cameroon)

Details

Type

Article

Created At

22 Jan 2023