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187681

Role of hemogram-derived ratios and systemic-Immune inflammation index in prediction of COVID-19 progression in Egyptian patients

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases
Medical virology

Abstract

Background: Early detection of COVID-19 patients with potentially severe disease is crucial for predicting the disease's course and prioritizing medical resources, lowering overall disease mortality. Objectives: To explore the role of baseline hemogram-derived ratios and systemic-immune inflammation index (SII), in addition to C-reactive protein (CRP), in predicting COVID-19 severity and prognosis. Methods: In this retrospective study, data were collected from the medical records of 425 COVID-19 patients. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII, together with the CRP, were investigated and compared. Results: NLR, PLR, SII, and CRP increased significantly in severe cases and with ICU admission (p < /em> ≤ 0.001). But, in non-survivors, only NLR and CRP were significantly elevated (p < /em><0.05). By interpreting area under the receiver operating characteristic curve (ROC-AUC), CRP and NLR were better predictors of disease severity (AUC: 0.7 for both), the need for ICU admission (AUC: 0.763 and 0.727, respectively), and in-hospital mortality (AUC: 0.812 and 0.75, respectively). SII was significantly associated with the risk of severe disease development (odds ratio (OR): 3.143; 95% confidence interval (CI): 1.101-8.976); CRP (OR: 2.902; CI95%: 1.342-6.273) and NLR (OR: 2.662; CI95%, 1.072-6.611) were significantly associated with ICU admission risk; and only CRP was significantly associated with in-hospital mortality risk (OR: 3.988; CI95%: 1.460-10.892). Conclusions: Values of CRP, SII, and NLR at the time of hospital admission could be independent prognostic biomarkers to predict COVID-19 progression.

DOI

10.21608/mid.2021.84684.1168

Keywords

COVID-19, Inflammation index, Lymphocyte Ratio, mortality, progression

Authors

First Name

Sara

Last Name

Taha

MiddleName

I.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dr_sara_ib@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-8224-8701

First Name

Sara

Last Name

Samaan

MiddleName

F.

Affiliation

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr.sara_farid@yahoo.com

City

Cairo

Orcid

-

First Name

Shereen

Last Name

Baioumy

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt.

Email

drshereenatef@yahoo.com

City

-

Orcid

0000-0002-2188-6790

First Name

Aalaa

Last Name

Shata

MiddleName

K.

Affiliation

Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

aalaashata@yahoo.com

City

-

Orcid

-

First Name

Aya

Last Name

Moussa

MiddleName

H.

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ayahisham@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4680-2204

First Name

Shaimaa

Last Name

Abdalgeleel

MiddleName

A.

Affiliation

Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt.

Email

shaimaa.abdalgeleel@nci.cu.edu.eg

City

-

Orcid

0000-0003-0994-7703

First Name

Mariam

Last Name

Youssef

MiddleName

K.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr.mariam_karam@hotmail.com

City

-

Orcid

0000-0003-2075-3889

Volume

2

Article Issue

4

Related Issue

28168

Issue Date

2021-11-01

Receive Date

2021-07-02

Publish Date

2021-11-01

Page Start

613

Page End

622

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 2_Issue 4_Pages 613-622.pdf

PDF . 414.2kB

Link

https://mid.journals.ekb.eg/article_187681.html

Detail API

https://mid.journals.ekb.eg/service?article_code=187681

Order

4

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Role of hemogram-derived ratios and systemic-Immune inflammation index in prediction of COVID-19 progression in Egyptian patients

Details

Type

Article

Created At

22 Jan 2023