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175134

Hepatitis B virus infection among patients with rheumatoid arthritis in Suez Canal University Hospital

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Infectious diseases
Medical virology

Abstract

Background: About 350 million individuals are considered having hepatitis B virus (HBV) infections worldwide, and 6.8% of cases have been observed of a reactivation of HBV triggered by immunosuppressive medications. Due to HBV reactivation, biologic or non-biological Synthetic antirheumatic disease-modifying drugs may be involved. For rheumatologists, HBV infection is a big concern. Patients and Methods: A descriptive cross-sectional study was carried out at Rheumatology outpatient clinic at Suez Canal University Hospital, Ismailia, during the period from 22 of January to 30 of July 2020 and included 200 patients with a history of Rheumatoid Arthritis. Patients were asked about their demographics and possible risk factors, and blood samples were collected for detection of HBV markers. Results: Evidence of present or past HBV infection with positive anti-HBc was found in 12% of patients (n=24). Among them, 4 patients had Overt HBV infection with positive HBsAg (2%) and another 4 patients had Occult hepatitis B, with negative HBsAg and positive HBV DNA (2%). Regarding HBV vaccination status, we found that 4 patients (16.7%) of HBc Ab positive patients were vaccinated and 69 patients (39.2%) of HBc Ab negative patients were vaccinated. Conclusion: This research indicates that HBV among rheumatoid arthritis patients is comparatively prevalent. Moreover, HBV carriers experience rheumatological symptoms. Risk factors for HBV infection in patients with Rheumatoid Arthritis included history of needle stick injury, dental visits, and prior surgical procedures.

DOI

10.21608/mid.2021.71083.1141

Keywords

Hepatitis B virus, Rheumatoid Arthritis, HBV DNA, HBV vaccine

Authors

First Name

Nashaat

Last Name

Soliman

MiddleName

-

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

nnashaat@yahoo.com

City

Ismailia

Orcid

-

First Name

Tasneem

Last Name

Fahmey

MiddleName

-

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

tasneem@yahoo.com

City

Ismailia

Orcid

-

First Name

Mohamed

Last Name

Hefny

MiddleName

-

Affiliation

Department of Rheumatology and Physical Medicine, Faculty of Medicine Suez Canal University, Ismailia, Egypt.

Email

hefney@hotmail.com

City

Ismailia

Orcid

-

First Name

Rania

Last Name

Kishk

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

rankishk@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Gaber

MiddleName

-

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

gaber32@yahoo.com

City

Ismailia

Orcid

-

Volume

2

Article Issue

3

Related Issue

26240

Issue Date

2021-08-01

Receive Date

2021-04-05

Publish Date

2021-08-01

Page Start

451

Page End

457

Print ISSN

2682-4132

Online ISSN

2682-4140

Link

https://mid.journals.ekb.eg/article_175134.html

Detail API

https://mid.journals.ekb.eg/service?article_code=175134

Order

10

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023