Antimicrobial stewardship entails every provider selects “The right antibiotic, for the right indication (right diagnosis), the right patient, at the right time, with the right dose and route, causing the least harm to the patient and future patients." If followed strictly, these principles ensure that providers only prescribe antibiotics for non-self-limiting bacterial infections. Depending on the clinical setting antimicrobial stewardship programs will target their goals and outcomes based on available resources and opportunities. Those goals fall under the following categories: 1) Improve patient care and outcomes.  2) Reduce collateral damage and 3) Impact costs. We will present two cases to discuss how to apply principles of prudent antimicrobial prescribing.