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135125

Effect of Meropenem-Colistin and Meropenem-Amikacin Combinations against Carbapenem-Resistant Pseudomonas aeruginosa Isolates in Suez Canal University Hospitals

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Infection prevention and control
Medical bacteriology

Abstract

Background: Healthcare associated infections (HAIs) caused by carbapenem-resistant P. aeruginosa are considered as an overwhelming problem in hospitals due to its resistance to most effective antibiotic classes. Consequently, various antimicrobial combinations have been suggested as an alternative in clinical practice. So, our aim was to improve the antibiotic policy in Suez Canal University Hospitals (SCUHs) in the treatment of carbapenem-resistant Pseudomonas aeruginosa infections and to reduce morbidity and mortality rates due to these infections.
Materials and methods: A cross-sectional descriptive study was carried out on 36 Carbapenem-resistant Pseudomonas aeruginosa strains collected from different wards in SCUHs. A checkerboard assay was carried on these strains to assess the effect of meropenem colistin and meropenem-amikacin combination.
Results: the synergy testing of the meropenem-amikacin combination on Carbapenem-resistant Pseudomonas aeruginosa showed 50% synergy, 8.3% addition, 36% indifference and 5.7% antagonism. For the meropenem-colistin combination, it showed 39% synergism, 30.5% addition and 30.5% indifference with no antagonism was observed. Although, the mean FIC value of meropenem was higher in the meropenem-amikacin combination than in the meropenem-colistin combination, the difference was statistically insignificant.
Conclusions: Both combinations (meropenem colistin and meropenem-amikacin) showed high rates of synergy and reduction of meropenem MICs against Carbapenem-Resistant Pseudomonas aeruginosa Isolates and can offer good alternatives in the clinical practice for treatment of CRPA strains.

DOI

10.21608/mid.2021.53173.1096

Keywords

P.aeruginosa, Colistin, Amikacin, Meropenem, checkerboard technique.  

Authors

First Name

Hasnaa

Last Name

Mahmoud

MiddleName

-

Affiliation

Microbiology And Immunology Department, Faculty Of Medicine, Suez Canal University Round Road 4.5km

Email

hasnaamahmod5@gmail.com

City

Ismailia

Orcid

-

First Name

Sahar

Last Name

Zakaria

MiddleName

-

Affiliation

Microbiology And Immunology Department, Faculty Of Medicine, Suez Canal University Round Road 4.5km

Email

saharmicrobiology@yahoo.com

City

Ismailia

Orcid

-

First Name

Rania

Last Name

Kishk

MiddleName

-

Affiliation

Medical microbiology and immunology faculty of medicine Suez Canal University, Egypt

Email

rankishk@yahoo.com

City

-

Orcid

-

First Name

Amro

Last Name

Al-Amir

MiddleName

-

Affiliation

Microbiology And Immunology Department, Faculty Of Medicine, Suez Canal University Round Road 4.5km

Email

amrolamir@yahoo.com

City

Ismailia

Orcid

-

Volume

2

Article Issue

2

Related Issue

23721

Issue Date

2021-05-01

Receive Date

2020-12-02

Publish Date

2021-05-01

Page Start

308

Page End

316

Print ISSN

2682-4132

Online ISSN

2682-4140

Link

https://mid.journals.ekb.eg/article_135125.html

Detail API

https://mid.journals.ekb.eg/service?article_code=135125

Order

16

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Effect of Meropenem-Colistin and Meropenem-Amikacin Combinations against Carbapenem-Resistant Pseudomonas aeruginosa Isolates in Suez Canal University Hospitals

Details

Type

Article

Created At

22 Jan 2023