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153628

Association of blood groups with the clinical presentation of COVID-19 infection.

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases
Medical virology

Abstract

Background: Blood groups' antigens, represent polymorphic traits inherited among populations, their expression differences, can increase or decrease the host susceptibility to infections. We aimed here to correlate the relation between the different blood groups and hosts' susceptibility towards COVID-19 infection. Methods: 355 samples, were analyzed for SARS-CoV-2 and blood groups typing. The candidates were then divided according to their results into; 210 positive-PCR (viral persistent, clearance and ICU admitted), and 145 negative-PCR contacts and then this results were compared. Results: The highest frequency in control and viral clearance group was O-phenotype, followed by A-phenotype and the least was AB-phenotype. The highest frequency in the viral persistent group, was A-group, showed followed by B-group and the least was O-group. Lastly in ICU group, A-group was the highest frequency, followed by O-group and the least was B-group. Using Chi-square method, a statistically significant result was observed (p-value= 0.034). Conclusions: The blood group-O was the protective phenotype, controversy to the O-group, A-group was the risky phenotype, also AB-group was risky, as it showed the lowest frequency in both control and viral clearance group. Interestingly, the B-group was the least group susceptible to have bad prognosis and be admitted to the ICU. This can be a safety guideline for classifying healthcare workers, according to their ABO, to work with suspected cases with COVID-19 and also may help in developing specific anti- histo-blood group antibodies as an effective co-therapy for COVID-19.

DOI

10.21608/mid.2021.59111.1111

Keywords

SARS-CoV-2, ABO-blood grouping, COVID-19, Real-Time PCR

Authors

First Name

Yara

Last Name

Shamikh

MiddleName

-

Affiliation

Department of microbiology and immunology, Faculty of Pharmacy, Nahda University, Beni-Suef, 62513, Egypt. Egypt centre for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt

Email

yara.shamikh@hotmail.com

City

New Cairo City

Orcid

0000-0001-7535-459X

First Name

Azza

Last Name

Salamony

MiddleName

-

Affiliation

Consultant, microbiology and immunology, Central public health laboratories, CPHL, Ministry of Health, Cairo, 11613, Egypt. Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

azzasalamony@yahoo.com

City

Giza

Orcid

0000-0003-4606-2779

First Name

Khaled

Last Name

Amer

MiddleName

-

Affiliation

Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

dramertx@gmail.com

City

Cairo

Orcid

0000-0001-6896-9449

First Name

Mostafa

Last Name

Elnakib

MiddleName

-

Affiliation

Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

moselnakib@yahoo.com

City

-

Orcid

-

First Name

Wael

Last Name

Hassan

MiddleName

-

Affiliation

Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

waelali@waelali.com

City

Giza

Orcid

0000-0001-5998-9106

First Name

Sagy

Last Name

Elzalabany

MiddleName

-

Affiliation

Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

phd.sagy@gmail.com

City

-

Orcid

-

First Name

Salem

Last Name

Reda

MiddleName

-

Affiliation

Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

salemredasalem@yahoo.com

City

-

Orcid

-

First Name

maha

Last Name

abdelsalam

MiddleName

-

Affiliation

Immunology unit, Clinical pathology department, Faculty of medicine, Mansoura University, Mansoura, 35516, Egypt. Egypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.

Email

dr_mahy20062006@yahoo.com

City

madinaty

Orcid

0000-0002-8160-8960

Volume

2

Article Issue

2

Related Issue

23721

Issue Date

2021-05-01

Receive Date

2021-01-21

Publish Date

2021-05-01

Page Start

224

Page End

231

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 2_Issue 2_Pages 224-231.pdf

PDF . 331.6kB

Link

https://mid.journals.ekb.eg/article_153628.html

Detail API

https://mid.journals.ekb.eg/service?article_code=153628

Order

7

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023