Background: In contributing to solving the global challenge of antimicrobial resistance, an in- vitro experiment was conducted to evaluate the antibacterial potential of ethyl alcohol leaf extract of Chrysophyllum albidum (G. Don)against five clinical pathogenic microorganisms namely: Escherichia coli (EC), Proteus mirabilis (PM), Pseudomonas aeruginosa (PA), Staphylococcus aureus (SA), and Salmonella typhimurium (ST).Methods: Agar well diffusion method was adopted and the exhibited zones of inhibition by the isolates were measured, and taken as the antimicrobial potential of the extract. Phytochemical screening of the leaf extract revealed the presence of tannins, saponins, terpenoids, steroids, flavonoids and cardiac glycosides. Sixteen different concentrations (0.003 – 100 mg/mL) of the extract were prepared to establish the minimum inhibitory concentrations (MICs). Results: The MICs ranged between 0.006 - 0.195 mg/mL. SA with MIC of0.006 mg/mL was the most sensitive isolate to the extract while E. coli was actively resistant. PA was resistant to all the tested (control) commercial antibiotics but highly sensitive to the extractwith MIC of 0.195mg/mL. Conclusion: It was concluded that C. albidum is a medicinal plant possessing a broad spectrum antimicrobial activities and hence could be explored for the production of antibiotic by phyto-pharmaceutical establishments.