Coronavirus virus disease 2019 (COVID-19) is one of the challenges to the global public health. With COVID-19 impacts across all sectors, the most glaring one is its impact on antibiotic resistance, another silence pandemic. Antibiotic resistance is at a crossroads of becoming a major killer and the emergence of COVID-19 pandemic aggravate the threat, due to excessive and extensive  use of antibiotics in the treatment package of COVID-19 despite being a viral pneumonia and for prophylaxis to prevent bacterial co-infection. Low bacterial co-infections were associated with COVID-19, but large antibiotics were employed, this challenged the principles of antibiotic stewardship, thus, further complicate the antibiotic stewardship guidelines.  This review revolves to highlight the effect of COVID-19 pandemic and its impacts on bacterial co-infections as well as how it fuels the already existing silent pandemic; antibiotic resistance which is waiting to unleash its effect on public health and socioeconomic sectors. While there is increase focus on COVID-19 pandemic, the review urged that focus should not be taken off on antibiotic resistance.