The COVID-19 outbreak has occurred for more than ten months. Some COVID-19 complications are still unknown. Is there any long-term effect on the neurologic manifestations after COVID-19? Will the infected patient get a greater risk of Alzheimer's disease? May the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a long latency period in the Central Nervous System (CNS)? If this is possible, it has various non-specific inflammatory diseases that initiate and re-activate certain inflammatory or oxidative reactions in Alzheimer's disease, but the neurological complications of COVID-19 are limited to individual cases or small case series according to several published papers.
Recently, Varatharaj et al. reported the neurological and neuropsychiatric complications of COVID-19 in 153 patients who were divided into two groups, cerebrovascular and neuropsychiatric. 96% of patients with cerebrovascular events are also altered with mental status in the age range from 71 to 80. The results showed 43% of patients with neuropsychiatric disorders would have a new-onset psychosis such as neurocognitive, dementia, and Alzheimer's disease. (To be continued)...