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86319

Silver nanoparticles: A potential antibacterial and antibiofilm agent against biofilm forming multidrug resistant bacteria

Article

Last updated: 22 Jan 2023

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Subjects

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Tags

Medical bacteriology

Abstract

Background: Multi-drug resistant (MDR) bacteria are seriously endangering the antibiotics. Different alternative strategies are needed to reinforce antibiotics, of, these; nanostructured materials may play a fruitful role. This study aimed to investigate the antibacterial and antibiofilm activity of silver nanoparticles (AgNPs) against MDR bacteria. Methods: In a cross-sectional study, a total of 33 methicillin resistant Staphylococcus aureus (MRSA) and 52 MDR Pseudomonas aeruginosa (P. aeruginosa) isolates were recovered from intensive care units' (ICUs) admitted patients over a period of 9 months, from December 2017 to August 2018. The antibacterial activity of AgNPs on the clinical isolates of MRSA and MDR P. aeruginosa was assessed by minimum inhibitory concentrations (MICs) using broth microdilution method. The minimum bactericidal concentrations (MBCs) were determined as the lowest concentrations required to kill 99.9% of the initial inoculum. Tissue culture plate method was used to evaluate the antibiofilm activity. Results: The MIC and MBC values ranged from 1 to 16 μg/ml and 2 to 64 μg/ml, respectively. Silver nanoparticles exerted a significant antibiofilm activity against MRSA and MDR P.aeruginosa at all tested concentrations, recording a maximum inhibition value of (82%) and (91%), respectively. Conclusions: AgNPs exhibited a considerable antibacterial and antibiofilm, effect; it could represent a promising weapon in the fight against biofilm forming MDR organisms.

DOI

10.21608/mid.2020.28087.1008

Keywords

silver nanoparticles, multidrug resistant, MRSA, P. aeruginosa

Authors

First Name

Gehan

Last Name

El-Shennawy

MiddleName

-

Affiliation

Medical Microbiology and Immunology department, Faculty of medicine, Zagazig University, Egypt

Email

nehalanwar50@gmail.com

City

-

Orcid

-

First Name

Randa

Last Name

Abd Ellatif

MiddleName

-

Affiliation

Medical Microbiology and Immunology department, Faculty of medicine, Zagazig University, Egypt

Email

randasaddek.rs@gmail.com

City

-

Orcid

-

First Name

Shahenda

Last Name

Badran

MiddleName

-

Affiliation

Medical Microbiology and Immunology department, Faculty of medicine, Zagazig University, Egypt

Email

shahendagamal0000@gmail.com

City

Zagazig

Orcid

-

First Name

Rehab

Last Name

El-Sokkary

MiddleName

-

Affiliation

Associate professor of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt

Email

rehab_elsokkary@yahoo.com

City

Zagazig

Orcid

0000-0002-8135-7671

Volume

1

Article Issue

2

Related Issue

13104

Issue Date

2020-08-01

Receive Date

2020-03-16

Publish Date

2020-08-01

Page Start

77

Page End

85

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 1_Issue 2_Pages 77-85.pdf

PDF . 507.7kB

Link

https://mid.journals.ekb.eg/article_86319.html

Detail API

https://mid.journals.ekb.eg/service?article_code=86319

Order

8

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023