Burullus Lake is one of five coastal lagoons exhibited by the northern Egyptian Mediterranean coast along the Nile Delta coast. The Lake has great economic importance as a wetland, fishery, and resting area for migrating birds, so it is designated a wetland nature reserve under the International Ramsar convention of 1988. It has been declared a nature reserve in Egypt since 1998. It is a shallow brackish lake connected to the Mediterranean by a small outlet (Boughaz) and connected to the western branch of the Nile by a small canal (Brimbal Canal). Because of its central location, the Lake receives most of the drainage water of the Nile Delta region through eight drains. As a result, the lake ecosystem has deteriorated environmentally. An appropriate plan for saving and developing the Northern Lakes of Egypt is urgently required. For this, using Sentiel and Landsat satellite imageries of Lake Burullus in the period 1973-2018, To extract water feature, and vegetation features from imageries, the Normalized Difference Water Index (NDWI) and the Normalized Difference Vegetation Index (NDVI) were applied. The multi-temporal maps of the lake surface area are overlaid to produce a map for the changes in the lake surface area using Geographic Information System (GIS), combined with surface measurements for mapping water quality parameters of Burullus Lake. All of the previous integrated for assessing and managing the threats and problems in the Lake.