In this paper a combination process for sub-carrier pulse modulation (SC- LPPM) technique with M-ary Quadrature Amplitude Modulation OFDM (M-QAM OFDM) under distinctive and uniform lighting topologies assumption in a typical room is introduced. It can be shown in the manuscript that under distinctive lighting topology assumption, utilizing M-QAM OFDM with a single carrier modulation technique (SCM) like SC- LPPM can enhance the operating bit rate performance up to 50 Mbps with a remarkable BER performance of 8.6x10-5 at modulation level (L=8), which can maintain a reliable communication link for Visible Light Communication (VLC) systems. Meanwhile, further improvement to the BER performance up to 9.56x10-6 can be achieved for the same modulation level at 5 Mbps bit rate. Moreover, an investigation for the power performance of the proposed technique, the minimum required power and the power distribution across the presented room topologies is presented in the manuscript under two scenarios (i.e., with and without utilizing SC- LPPM with M-QAM OFDM), which will give an insight into the performance enhancement that occurred due to the utilization of optical OFDM.