Aim: is to assess the impact of counseling on quality of life (QoL) and treatment adherence. Research designs: A quasi experimental research design. Settings: The study was conducted at the pediatric unit in National Cancer Institute affiliated to Cairo University. Subjects: A purposeful sample included (30) children newly diagnosed with “Acute Lymphoblastic Leukemia" in the initial diagnosis period and received chemotherapy treatment at the first day of induction phases their age start from 6 to18 years, and they been accompanying with their mothers and admitted to the previously mentioned setting. Tools: data collected was a structured interviewing questionnaire, Kids Screen-Scale to assess quality of life, pre and post counseling and Medication Adherence Scales to assess treatment adherence post counseling. Results: The study results revealed that there are a highly statistically significant difference on quality of life of children pre and post counseling, as well as children had high adherence to treatment post counseling. Conclusion: The counseling had a positive effect on children adherence to Acute Lymphoblastic Leukemia treatment, which lead to promote the quality of life. Recommendation: Recommendations: The study recommended the application of the counseling session for all Acute Lymphoblastic Leukemia children and their mothers to improve their adherence to treatment   to promote their quality of life.