This article presents the development of expert system application that mimics the steps done by healthcare providers who are responsible for determining the type of spine injury by using the algorithm of AOSpine thoracolumber spine injury classification. The expert system is capable of recommending the type of spine fracture; this recommendation done by the proposed expert system will facilitate the selection of treatment and referral of the patients to the specialized healthcare unit. The source of knowledge used in the proposed expert system was collected from various related literature studies and spine surgeons. The proposed expert system was evaluated by a group of spine surgeons at the spine unit, College of Medicine, Zagazig University, Egypt. The proposed expert system was then evaluated in terms of its functionality, usability, and reliability using the ISO/IEC 9126 software quality standards. The results showed that the proposed expert system was able to achieve the defined objectives of this study.